Genome Mapping, Assembly and Comparison

This quiz contains multiple-choice problems on genome mapping and sequencing, genome sequence assembly, genome annotation and comparative genomics.

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Which of the following is incorrect regarding genome mapping?

It does not lead to the understanding of a genome structure

It involves identifying relative locations of genes

It involves identifying traits

It involves identifying mutations

Genetic markers are __ portions of a __ whose inheritance patterns can be followed.

unidentifiable, genes

unidentifiable, chromosome

identifiable, chromosome

identifiable, genes

Genetic linkage maps, also called genetic maps, identify the relative positions of genetic markers on a chromosome and are based on how frequent the markers are inherited together. True or false?

True

False

One centimorgan is defined as __ percentage of the total recombination events.

One

Ten

0.1

0.01

Physical maps are locations maps of identifiable landmarks on genomic DNA __ inheritance patterns.

Remotely related to

Related to

Regardless of

Associated with

Physical maps are constructed using a chromosome walking technique. True or false?

True

False

Which of the following is incorrect regarding cytologic maps?

They cannot be directly observed under microscope

They refer to banding patterns

They can be viewed on stained chromosomes

They can be directly observed under microscope

Cytologic maps can be considered of __ resolution and somewhat __ physical maps.

very high, inaccurate

very low, accurate

very high, accurate

very low, inaccurate

In medical applications, the ultimate goal of gene mapping is to disease genes. True or false?

True

False

One of the fundamental events in meiosis is crossing over in which homologous chromosomes exchange segments causing a reshuffling of genes. True or false?

True

False

Which of the following is incorrect regarding base calling and assembly programs?

The first step toward genome assembly includes derive base calls

The first step toward genome assembly includes assigning associated quality scores

One of the steps is to assemble the sequence reads into contiguous sequences

There is no identifying overlap between sequence fragments

Which of the following is incorrect about Phred?

It is a UNIX program

It does not give a probability score in output

It is used for base calling

It uses a Fourier analysis to resolve fluorescence traces and predict actual peak locations of bases

Which of the following is incorrect about Phrap?

It aligns individual fragments in a pairwise fashion using the Smith–Waterman algorithm

It does not take input from Phred

It is used for sequence assembly

It is a UNIX program

VecScreen is primarily aimed at sequence assembly. True or false?

True

False

Which of the following is incorrect about EULER?

It is an assembly algorithm

It uses a Eulerian Superpath approach, which is a polynomial algorithm

In this approach, a sequence fragment is broken down to tuples of five nucleotides

The tuples are distributed in a diagram with numerous nodes that are all interconnected

Quiz/Test Summary
Title: Genome Mapping, Assembly and Comparison
Questions: 15
Contributed by:
Ivan