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This quiz contains multiple-choice problems on gene functional classification, global gene regulation, and gene function prediction.
Which of the following statements is false?
Paralogous sequences, frequently are found to have dissimilar functions
An early classification scheme for eight related groups of E. coli genes included categories for enzymes, transport elements
An early classification scheme for eight related groups of E. coli genes included categories for regulators, membranes, structural elements, protein factors, leader peptides, and carriers
Ninety percent of E. coli genes related by significant sequence similarity fell into these same broad categories
An approach to the classification of genes that encode enzymes is to examine relationships among multiple enzymes that perform the same biochemical function in the same organism. True or false?
True
False
Other functional classification schemes for genes include a broader category for genes involved in the same biological process, e.g., a three-group scheme for energy-related, information-related, and communication-related genes has also been used. True or false?
True
False
Two species that have recently diverged from a common ancestor are expected to have a __ set of genes and __ chromosomes with these genes positioned along the chromosomes in the same order.
distinct, similar
similar, distinct
similar, dissimilar
similar, similar
Once a set of co-regulated genes has been found, their promoter regions may be analyzed for conserved patterns representing interaction sites with specific transcription factors. True or false?
True
False
In cluster analysis of microarray data, a node is created between the __ scoring pair, the gene-expressed profiles of these two genes are averaged, and the joined elements are weighed by the __ of elements they contain.
lowest, frequency
average, sequence
lowest, number
highest, number
SVMs (Support vector machines) are a binary classification method to discriminate one set of data points from another. True or false?
True
False
GeneQuiz focuses on deriving a predicted protein function based on various available evidence, including the similarity evaluation of the closest homolog in a database. True or false?
True
False
The designation ECa.b.c.d conveys information. Which of the following is not it?
One of twelve main classes of biochemical reactions
The group of substrate molecule
The nature of chemical bond that is involved in the reaction
Designation for acceptor molecules (cofactors)
Which of the following statements is incorrect regarding genes?
In a given organism or species, genes are found in a given order that is maintained on the chromosomes from one generation to the next
Genes with a related function are frequently found to be distorted on a chromosome
A possibility is that there is genetic variation (alleles) within each gene in a cluster of a given species and that only certain allelic combinations of different genes are compatible
Clustering of related genes presumably provides an evolutionary advantage to a species
Which of the following statements is incorrect regarding chromosomal rearrangements?
Comparison of the number of rearrangements in a given period of evolutionary history may vary significantly from one organism to the next
If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, there is an increased probability of an ortholog of B also occurring in the other organism
If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, the B ortholog is more likely to be a neighbor of the A ortholog of the genome of the second species if the two species are more divergent
In general, the order of orthologs is not well conserved in prokaryotes when the genomes have diverged sufficiently that the orthologs have < 50% identity
Which of the following statements is incorrect regarding MAGPIE?
It analyzes the genome using a set of automated processes
It is designed for high-throughput genome sequence analysis
It is unable to locate potential promoters
It automatically annotates genomic sequence data and maintains a daily up-to-date record in response to user queries about one or more genomes
Which of the following statements is incorrect regarding microarray analysis?
It is designed to detect global changes in transcription in a genome
It provides information about the levels of protein products of the genes
The proteins are first separated in a column on the basis of size and then across a second dimension on a slab on the basis of charge
Labeled protein samples may also be extracted from treated cells and separated by two-dimensional gel electrophoresis
Which of the following statements is incorrect about observations made with regard to gene order?
Order is highly conserved in closely related species
Order in closely related species becomes changed by rearrangements over evolutionary time
As more and more rearrangements occur, there will no longer be any correspondence in the order of orthologous genes on the chromosome of one organism with that of a second organism
Order is less conserved in closely related species
In cluster analysis of microarray data, the process is repeated __ times for n genes until a single element remains.
n^2
n
n^(-1)
n^(-4)
